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Acute _transplant_rejection

Etiology: • The etiology of organ transplant rejection is complex, basically immunological.

Pathogenesis: • The pathogenic mechanisms are complex, basically immunological.

Epidemiology: • Transplanted kidney is being recognized as foreign by the patients immune system.

General Gross Description: • Grossly, the kidney may vary from unremarkable to necrotic, depending on the extend and stage.

General Microscopic Description: • The most characteristic changes involve the arterial vasculature. • The thickened intima shows inflammatory cell infiltrates and there may be infiltrates of the muscular walls as well. • Occlusive vascular thrombosis may be present.

Clinical Correlations: • Patients with transplanted kidneys are closely monitored and the clinical manifestations will be that of decreasing renal function.

References: •The Renal Biopsy (Striker,Olson, Striker Eds.) 1990, pp. 232-235.