[Search-frames]

[Search-no frames]

[UCHC Home]

[©]

[Feed Back]

[About]

Non-ossifying fibroma

Etiology: • Unknown

Pathogenesis: • Probably represent developmental defects, rather than neoplasms.

Epidemiology: • Extremely common. • Found in as many as 30 to 50% of children older than two years.

General Gross Description: • Usually found in the lower limb. • Found to arise eccentrically from the metaphysis of the bones around the knee joint.

General Microscopic Description: • Histologically composed of benign fibroblasts. • Frequently associated with foamy macrophages.

Clinical Correlations: • Asymptomatic. • Radiologically produce sharply demarcated lucent areas in bone. • Usually found as an incidental, asymptomatic finding on routine x-rays. • Results spontaneously, and are replaced by normal bone. • May result in pathological fracture, if they do not spontaneously resolve.

References: •Robbins "Pathologic Basis of Disease". (Cotran, Kumar and Robbins, Eds.) 5th Edition. pp 1241.