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Malignant Fibrous Histiocytoma

Etiology: • Unknown

Pathogenesis: • Pathological fractures are caused by destruction of bone by the tumor.

Epidemiology: • Occur somewhat more frequently in men.

General Gross Description: • Grossly, they are large tan masses that are frequently associated with hemorrhage. • They arise in the soft tissue of the body, and can erode into bone and soft tissues.

General Microscopic Description: • Histologically, MFH consists of spindling fibroblasts with large numbers of bizarre, multi-neucleated giant cells. • There is a tendency of some of the mononuclear cells to resemble histiocytes. • This is a high grade, very aggressive tumor.

Clinical Correlations: • These are usually present as enlarging, painful masses that often cause pathological fractures. • The prognosis is poor with a 20% survival at five years.

References: •Robbins "Pathologic Basis of Disease". (Cotran, Kumar and Robbins, Eds.) 5th Edition. pp 1243.