<B>Hodgkin's Disease, Lymphocyte Depleted </B>

[©]

Hodgkin's Disease, Lymphocyte Depleted

Etiology:

• Unknown

Pathogenesis:

• Unlike other forms of Hodgkin's disease relatively large population of neoplastic cells
• Marked inflammatory reaction driven by cytokines secreted by neoplastic cells including IL 5 (attracting eosinophils), IL4, tumor necrosis factor alpha, GM-CSF

Epidemiology:

• 0.7% of all new cancers in the U.S. are Hodgkin's Disease
• Present in older population
• Relatively rare

General Gross Description:

• Small, firm lymph nodes

General Microscopic Description:

• Large numbers of diagnostic Reed Sternberg cells and mononuclear variants which are CD15+, CD30+, CD45-, CD20-
• Background shows scant lymphocytes and may show abundant reticulin deposition or fibrosis

Clinical Correlations:

• Usually involves multiple lymph node groups
• Least likely to respond well to treatment

References:
• Jaffe ES, Surgical Pathology of the Lymph Nodes and related organs, second edition, W.B. Saunders; Philadelphia, 1995, pp.172-178.