<B>Hodgkin's Disease, Mixed Cellularity </B>

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Hodgkin's Disease, Mixed Cellularity

Etiology:

• Unknown

Pathogenesis:

• Relatively small population of neoplastic cells, which vary with subtype (see below)
• Marked inflammatory reaction driven by cytokines secreted by neoplastic cells includingIL 5 (attracting eosinophils), IL4, tumor necrosis factor alpha, GM-CSF

Epidemiology:

• 0.7% of all new cancers in the U.S. overall for Hodgkin's Disease
• Average age 32 years

General Gross Description:

• Enlarged, flesh gray tan lymph node without well defined nodules or fibrosis

General Microscopic Description:

• Numerous diagnostic Reed Sternberg cells and mononuclear variants which are CD15+, CD30+, CD45-, CD20-
• Mixed population in background of eosinophils, plasma cells, small lymphocytes and histiocytes

Clinical Correlations:

• May present involving multiple lymph node groups
• Responds well to treatment

References:
• Jaffe ES, Surgical Pathology of the Lymph Nodes and related organs, second edition, W.B. Saunders; Philadelphia, 1995, pp.166-171.