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Schwannoma

Etiology: • Unknown

Pathogenesis: • Proliferation of Schwann cells

Epidemiology: • Exceedingly rare

General Gross Description: • Well circumscribed, homogeneous gray-tan lesions attached to peripheral nerve

General Microscopic Description: • Composed of cells with delicate, elongated, wavy nuclei with pointed tips • Cytoplasm is palely eosinophilic • Regions of the neoplasm may exhibit lining up of the nuclei into bands of nuclei alternating with cytoplasm (Antoni A); cytoplasmic areas are termed Verocay bodies • Antoni B regions lack definite arrangement and may have microcysts

Clinical Correlations: • Benign lesion

References: Rosen PP, Oberman H. Tumors of the Mammary Gland. AFIP, Washington, 1993, pp. 311. • Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease 5th edition. W.B. Saunders, Philadelphia, 1994, pp. 1351-2.