[Search-frames]

[Search-no frames]

[UCHC Home]

[©]

[Feed Back]

[About]

Fibroadenoma

Etiology: • Unknown

Pathogenesis: • Stromal component of the lesion is clonal • Derives from intralobular stroma • May arise within individual nodules and apparently "coalesce"

Epidemiology: • Most common benign neoplasm in the breast • More frequent in women under 30

General Gross Description: • Gray-white, spherical nodule that is rubbery and mobile on palpation • Neoplasm can be "shelled out" of the surrounding breast tissue • In teenagers may reach enormous size (10-15 cms) so called juvenile fibroadenoma

General Microscopic Description: • Consists of a proliferation of both ducts and stroma • Stroma contains numerous fibroblasts and palely eosinophilic cytoplasm • Broad birefringent collagen bands are absent until lesion involutes • Glandular spaces are lined by typical duct epithelium and may be compressed by fibrous proliferation

Clinical Correlations: • Benign • Regress with menopause • Treatment by resection

References: • Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease 5th edition. W.B. Saunders, Philadelphia, 1994, pp. 1097-8.