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Lobular Carcinoma in situ

Etiology: • Unknown

Pathogenesis: • Unknown, ?BRCA1 mutations. • See discussion under invasive carcinoma of breast

Epidemiology: • Increasing age • More frequent in women of low parity with first child after 30 • Increased in obesity • Increased in women with history of atypical hyperplasia • Increased in women with history of breast carcinoma • Increased in women with mother or sibling with breast cancer • Increased in women with mutations in BRCA1 or BRCA2 genes

General Gross Description: • May be associated with microcalcifications within the lobules • Gross findings may be of fibrocystic change • May be associated with invasive carcinoma

General Microscopic Description: • Distension of terminal ducts or ductules by solidly packed cells • Cells are slightly larger than normal with round to oval nuclei and small nucleoli • Cells may extend up into ducts

Clinical Correlations: • Increased risk of breast cancer 10 fold

References: • Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease 5th edition. W.B. Saunders, Philadelphia, 1994, pp. 1099-1103.