zx1 19 zx2 Bone zx3 10 zx4 Bone zx5 Chondrosarcoma of the pelvis zx6 Chondrosarcoma zx7 G zx8 Malign zx9 zx0 zz1 •The specimen is a hemi-pelvis. Note the normal bones and muscles of the pelvis around the periphery. •The central part of the specimen (flanked by the white arrows) is the tumor. •Note the white, glistening appearance typical of chondrosarcomas. | zx1 47 zx2 GI zx3 infarcted_sbowel7001 zx4 Small Intestine zx5 Infarction of small intestine zx6 Infarct zx7 g zx8 Degen zx9 zx0 UCHC zz1 •This is a segment of small intestine (ileum) •Approximately 3/4 of the specimen shows transmural hemorrhage and infarction (the dark red region). The attached mesentery is also hemorrhagic. •This is the result of twisting of this loop of bowel about its mesentery (volvulus), thus impeding arterial flow and venous return. •Note the junction of the more normal appearing tan-pink bowel with the hemorrhagic bowel. | zx1 48 zx2 GI zx3 infarcted_sbowel7002 zx4 Small Intestine zx5 hemorrhagic infarction zx6 Infarct zx7 G zx8 Degen zx9 zx0 UCHC zz1 •This close-up image of the bowel serosa shows the junction of infarcted tissue (dark red) and more normal tan bowel •The line of demarcation is typically quite sharp (Arrow) •The omentum seen on the lower left attached to the bowel is also hemorrhagic | zx1 49 zx2 GI zx3 Acute_appendicitis7003 zx4 Appendix zx5 Acute Appendicitis - gross zx6 Appendicitis zx7 G zx8 Inf zx9 zx0 UCHC zz1 •This appendix has been cross sectioned at one end •The cross sectioned end appear dilated and the wall appears thickened and edematous •The serosa is congested with yellow plaques of exudate(arrow) •The serosal surface of the intact appendix shows congested vessels | zx1 50 zx2 GI zx3 adenoca_rectum7004 zx4 Colon zx5 Adenocarcinoma of rectum zx6 Adenocarcinoma zx7 G zx8 Malign zx9 zx0 UCHC zz1 •This colon has been opened longitudinally. •Note ulcerated mass with raised rolled borders(arrows). •The remaining mucosa is tan with normal folds. | zx1 51 zx2 GI zx3 adenoca_rectum7005 zx4 Colon zx5 Adenocarcinoma of rectum - close up zx6 Adenocarcinoma zx7 G zx8 Malign zx9 zx0 UCHC zz1 •Tumor is sharply demarcated from adjoining normal mucosa •Raised rolled borders(arrow) are common in colorectal carcinoma •Depressed center is necrotic tumor | zx1 52 zx2 GI zx3 adenoca_colon7006 zx4 Colon zx5 Adenocarcinoma with Lymph Node Metastases zx6 Adenocarcinoma zx7 G zx8 Malign zx9 zx0 UCHC zz1 •This is a view of the entire thickness of the colon wall and mesentery. •Note the mucosal tumor(white arrow) •Tumor involves full thickness of the muscularis propria advancing into the the pericolic fat(black arrow) •Multiple enlarged lymph nodes contain metastatic carinoma which is white to tan(green arrows) | zx1 53 zx2 GI zx3 cecal_tumor7007 zx4 Colon zx5 Adenocarcinoma of Cecum zx6 Adenocarcinoma zx7 G zx8 Malign zx9 zx0 UCHC zz1 •The cecum has been opened displaying the mucosal surface •A probe is in the ileocecal valve •The red tumor mass near the ileocecal valve has typical raised rolled clearly demarcated margins(arrow) •Adjoining normal mucosa is smooth, tan and has normal folds | zx1 57 zx2 GI zx3 BilcolicGallbladder7011 zx4 Gall Bladder zx5 Chronic Cholecystitis and cholelithiasis zx6 Cholecystitis,_Chronic zx7 G zx8 Inf zx9 zx0 UCHC zz1 •Partially opened gallbladder contains numerous yellow brown gallstones(black arrow). •Mucosa(green arrow) has lost its normal granular tan appearance. Smooth white appearance indicates fibrosis. | zx1 58 zx2 GI zx3 Focal_nod_hyper7012 zx4 Liver zx5 Focal Nodular Hyperplasia zx6 Focal_Nodular_Hyperplasia zx7 G zx8 Growth zx9 zx0 UCHC zz1 | zx1 59 zx2 GI zx3 Focal_nod_hyper7013 zx4 Liver zx5 Focal Nodular Hyperplasia zx6 Focal_Nodular_Hyperplasia zx7 G zx8 Growth zx9 zx0 UCHC zz1 | zx1 60 zx2 GI zx3 GIstromaltumor7014 zx4 Small Intestine zx5 Gastrointestinal Stromal Tumor(GIST) zx6 GIST zx7 G zx8 Malign zx9 zx0 UCHC zz1 •This opened segment of ileum has a mass protruding into the lumen which led to intussusception •The white tan fleshy cut surface has focal hemorrhage and cystic softening due to poor central vascularization related to tumor size •This mesenchymal tumor orignated in the muscularis and in this case grew into the lumen while in other cases it may grow outwards protruding from the serosa of the gut | zx1 61 zx2 GYN zx3 papserouscystadenoma7015 zx4 Ovary zx5 Papillary Serous Cystadenoma zx6 Cystadenoma_Serous zx7 G zx8 Benign zx9 zx0 UCHC zz1 •Bisected ovary exhibiting multiple cysts. •Some cysts show septations. •Smooth glistening lining. •No solid mass of neoplasm. •Fluid was clear, colorless and thin. | zx1 62 zx2 GYN zx3 uterus_accreta7016 zx4 Uterus zx5 Uterus with Placenta Percreta zx6 Percreta zx7 G zx8 Vasc zx9 zx0 UCHC zz1 •This is a uterus following ceserean section. •Note the vertical, anterior incision along the uterus. •Arrows show the defect in the uterine wall resulting from the invasion of the placenta through to the serosa. | zx1 63 zx2 GYN zx3 leiomyoma-outside7018 zx4 Uterus zx5 Uterine Leiomyomoma (external view) zx6 Leiomyoma zx7 G zx8 Benign zx9 zx0 UCHC zz1 •This is the external surface of a portion of the uterus containing an ovoid leiomyoma. •Smooth, bulging external surface. | zx1 65 zx2 Bone zx3 7020 zx4 Bone zx5 Chondrosarcoma lower end of humerus zx6 Chondrosarcoma zx7 G zx8 Malign zx9 zx0 UCHC zz1 •Note large whitish mass attached to bone. •Hemorrhage is denoted by the areas of red color. | zx1 66 zx2 GYN zx3 abruption7021 zx4 Placenta zx5 Abruptio placentae zx6 Abruption zx7 G zx8 Vasc zx9 zx0 UCHC zz1 •Cross section of placenta; fetal surface at top. •Long arrow = retroplacental hemorrhage. •Short arrows = area of infarcted villi due to compression. | zx1 67 zx2 GYN zx3 mo-motwin7017 zx4 Placenta zx5 Monochorionic-Monoamniotic Twin Placenta zx6 Twin_MoMo zx7 G zx8 Con zx9 zx0 UCHC zz1 •This is a twin placenta. Note the two umbilical cords. •There is no membrane dividing the two umbilical cords which is indicative of a monoamniotic placenta. •Note the entanglement of the umbilical cords. | zx1 70 zx2 GYN zx3 normal_membranes7024 zx4 Placenta zx5 Fetal membranes zx6 Normal_Membranes zx7 M zx8 Normal zx9 zx0 UCHC zz1 •This is a photo of fetal membranes. •Black arrow indicates the simple squamous to cuboidal amniontic epithelium. Note the layer of amniotic connective tissue beneath the epithelium. •There is artifactual separation of the amnion and chorion. •Blue arrow points to the trophoblast cells of the chorion which form a continuous layer. The connective tissue of the chorion is the thin layer just above the trophoblasts. | zx1 71 zx2 GYN zx3 monochor_Tzone7025 zx4 Placenta zx5 Monochorionic-Diamniotic Twin Placenta zx6 Twin_MoDi zx7 M zx8 Normal zx9 zx0 UCHC zz1 •This is a section of the dividing membranes of a monochorionic, diamniotic placenta. •Note that the dividing membrane is two amnions juxtaposed in back to back fashion. •The simple squamous amniotic epithelium lines the amniotic sac of each twin. | zx1 74 zx2 Skin zx3 skinscc7028 zx4 Skin zx5 Squamous Cell Carcinoma zx6 Squamous_Cell_Carcinoma zx7 G zx8 Malign zx9 zx0 UCHC zz1 | zx1 75 zx2 Bone zx3 MFH7029 zx4 Soft Tissue zx5 Malignant Fibrous Histiocytoma zx6 Malignant_Fibrous_Histiocytoma zx7 M zx8 Malign zx9 zx0 UCHC zz1 | zx1 76 zx2 Bone zx3 7030 zx4 Soft Tissue zx5 Anaplastic neoplasm of peripheral neuro-ectodermal origin zx6 Neuro_ectodermal_tumor zx7 G zx8 Malign zx9 zx0 UCHC zz1 •Large tumor in subcutaneous tissue •Note area of hemorrhage and ulceration at top. •This may have presented as a non-healing ulcer. | zx1 77 zx2 CV zx3 MI_muralthromb7031 zx4 Myocardium zx5 Healed anteroseptal myocardial infarct with mural thrombus zx6 Infarct_Old zx7 G zx8 Degen zx9 zx0 UCHC zz1 •Outflow tract of left ventricle. Note: aortic valve; endocardial surface of interventricular septum ( •); posterior papillary muscle arising from posterior left ventricular wall (white arrow); anterolateral wall of left ventricle (black arrow) •Mural thrombus (green arrow) filling concavity resulting from thinning of septal wall by fibrotic healed infarct. | zx1 78 zx2 GI zx3 bodystalkanomaly7032 zx4 Stomach zx5 Body-Stalk Anomaly zx6 Anomaly zx7 G zx8 Con zx9 zx0 UCHC zz1 •Body-stalk anomaly is a defect of abdominal wall closure as a manifestation of early amnion rupture •Abdominal viscera protrude into a thin membrane lined sac •Note the extruded liver(arrow) •The limbs are usually hypoplastic, a finding not present in this case | zx1 81 zx2 GI zx3 UCrectum7035 zx4 Colon zx5 Rectum - ulcerative colitis zx6 Ulcerative_Colitis zx7 G zx8 Inf zx9 zx0 UCHC zz1 •This segment of rectum has been opened longitudinally •Note the small red 1mm punctate ulcers throughout the specimen.(hard to see!) •Diffuse mucosal red color reflects congestion second to the diffuse mucosal inflammation •Anus is at left, white line(arrow) is Pectinate Line | zx1 84 zx2 GI zx3 appendicitis7038 zx4 Appendix zx5 Acute Appendicitis zx6 Appendicitis zx7 G zx8 Inf zx9 zx0 UCHC zz1 •Granular roughened serosa with marked congestion at tip (yellow arrow) •Grey yellow purulent exudate on the surface (green arrows) •Marked increase in diameter | zx1 86 zx2 GI zx3 UCrectum7040 zx4 Colon zx5 Rectum - Ulcerative Colitis - mucosa zx6 Ulcerative_Colitis zx7 G zx8 Inf zx9 zx0 UCHC zz1 •Anal mucosa(black arrow). •Large irregular mucosal ulceration of rectum (white arrow). •Focal mucosal hemorrhage (blue arrow) | zx1 87 zx2 GI zx3 analrectalca7041 zx4 Colon zx5 Adenocarcinoma of Rectum zx6 Adenocarcinoma zx7 G zx8 Malign zx9 zx0 UCHC zz1 •Carcinoma has a button-like appearance(arrow) with raised rolled margins •Hemorrhoidal polyps(green arrow) are seen at the anal-rectal junction | zx1 91 zx2 GI zx3 colonlow_grade_dys7045 zx4 Colon zx5 Colon - low grade dysplasia zx6 Dysplasia zx7 M zx8 Growth zx9 zx0 UCHC zz1 •Nuclear changes: hyperchromasia, cigar shaped nuclei. •Functional changes: decrease in mucin production. •Architectural changes: early loss of polarity with pseudopalisading. |