Metastatic Malignant Melanoma

Metastatic Malignant Melanoma •Cross section of a lymph node with extensive replacement by metastatic melanoma. •This lymph node is significantly enlarged and shows replacement of the tissue by dark black staining tissue. •Pigment production in this case is diagnostic of the metastatic lesion, namely a metastatic melanoma. •However, some melanomas may not produce melanin pigment in the the primary site and/or the metastatic site. •This sometimes creates a diagnostic dilemma. (Description By:T.V. Rajan M.D., Ph.D. ) (Image Contrib. by:Melinda Sanders, M.D. UCHC )