Ductal Carcinoma in situ (DCIS) (High Power)

Ductal Carcinoma in situ (DCIS) (High Power) • This close up view enables the diagnosis of DCIS to be made. • The yellow arrows point to the intact basement membrane, surrounded by delimiting fibroblasts. • The red arrows point to some neoplastic nuclei containing nucleoli. • No myoepithelial cells can be seen. • The cells have lost their normal relationship to the lumen so that the nuclei hang into the lumen. • The blue arrows point to some necrosis within the lumen (insufficient to make the diagnosis of comedo type carcinoma in situ). (Description By:Melinda Sanders, M.D. ) (Image Contrib. by: UCHC )