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Parathyroid Adenoma

Etiology: • unknown

Pathogenesis: • unknown • secretes unregulated parathormone resulting in elevation of serum calcium by renal retention, GI absorption and bone mobilization

Epidemiology: • 25/100,000 in US • 3:1 female predominance • age > 50

General Gross Description: • Single • Red-tan • Occasionally can see compressed rim of normal parathyroid

General Microscopic Description: • Composed of any cell types within parathyroid • No stromal or intracellular fat • May see compressed rim of normal parathyroid • Nuclear atypia and mitoses are NOT indicative of malignancy

Clinical Correlations: • usually detected in asymptomatic patient • rarely see evidence of osteitis fibrosa cystica (due to osteoclast activity and bone resorption) and renal stones

References: •Cotran Rs, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease. 5th edition. W.B. Saunders. Philadephia 1994. pp. 1144-146