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Malignant Mixed Mesodermal Tumor

Etiology: • Unknown

Pathogenesis: • unknown • some cases associated with endometriosis

Epidemiology: • Post-menopausal women • Low parity • Rare neoplasm

General Gross Description: • Large variegated lesions with areas of necrosis and hemorrhage • May have adhesions

General Microscopic Description: • epithelial component most often serous or endometrioid with focal squamous differentiation • stroma may be spindle cell or show cartilage, skeletal muscle, smooth muscles or other soft tissue differentiation

Clinical Correlations: • 2-3% of ovarian neoplasms • Post-menopausal women • Usually has spread in the peritoneal cavity at surgery • Debulking and chemotherapy ustilized

References: • Le T,Malignant mixed mesodermal ovarian tumor treatment and prognosis: a 20-year experience.Gynecol Oncol 65(2), 237-240(1997) • Dictor M, Malignant mixed mesodermal tumor of the ovary: a reportof 22 cases. Obstet Gynecol 65(5), 720-724 (1985)