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| Pyosalpinx |
| Etiology: • secondary to bacterial infection usually Chlamydia trachomatis or Neisseria Gonorrhae when sexually transmitted or • staphylococci, streptoccoci, or coliforms • organisms reach fallopian tube by ascending through cervix and across endometrium |
| Pathogenesis: • suppurative acute inflammatory response to organisms within the fallopian tube • may occur rapidly following vaginal inoculation with organism (3-5 days in experimental models) • may be facilitated by estrogen • fusion of the end of the tube results in purulent accumulation within the dilated tube |
| Epidemiology: • part of Pelvic Inflammatory Disease (P.I.D.) which may be • sexually transmitted disease or • follow delivery, abortion, instrumentation, or IUD placement • disease of reproductive age women |
| General Gross Description: • enlarged fallopian tube with hyperemic external surface which may show serositis • lumen filled with pus |
| General Microscopic Description: • acute inflammatory infiltrate within the lumen and involving epithelium of the tube |
| Clinical Correlations: • uterine tenderness and pain accompanying vaginal discharge • systemic symptoms of fever and malaise may be accompanied by leukocytosis • treatment with antibiotics • risk of infertility pronounced with development of pyosalpinx |
| References: • Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease. 5th edition. W.B. Saunders Philadelphia 1994. pp. 1039 |