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Normal Lung

Etiology: • Not applicable

Pathogenesis: • Not applicable

Epidemiology: • Not applicable

General Gross Description: • Weight 250-350 grams each • Soft, well aerated, pink tan • Often tracing of black carbon pigment outlining the subpleural macrophages

General Microscopic Description: • Bronchi, containing cartilage in their walls, branch to form bronchioles, lacking cartilage, ending in terminal bronchioles which give rise to respiratory bronchioles and then alveoli • Clara cells increase and goblet cells decrease progressing down the bronchial divisions. • Other cells include Kulchitsky (neuroendocrine cells) and ciliated columnar cells • Alveolar membrane includes type 1 pneumocytes,alveolar basement membrane, capillary basement membrane, and endothelial cells.

Clinical Correlations: • Not applicable

References: • Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease. 5th edition. W.B. Saunders. Philadelphia 1994. pp.673-674