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| Adenosquamous Carcinoma |
| Etiology • Associated with cigarette smoking • Radiation, air pollution and genetic predisposition may also play a role |
| Pathogenesis • BPDE (catabolite of benzo[a]pyrene in cigarette smoke) binds p53 mutational hot spots in lung carcinoma • p53 mutation affects cell replication and centromere replication • Usually neoplasm showing ability to differentiate in either direction, |
| Epidemiology • More frequent in males • Represents about 3.5% of resected lung carcinoma • Reserved for cases with large component of both types |
| General Gross Description • Large neoplasm that may resemble adenocarcinoma |
| General Microscopic Description • Both malignant squamous and glandular cells • Neoplastic elements may be intimately admixed |
| Clinical Correlation • Staging dependent on extent of disease ranging from I (confined to the lung with >2 cm distance from hilum and pleura) to IV (metastatic disease) • Metastatic disease to lymph nodes, brain, liver and adrenal glands • Surgical treatment is preferred; many patients have insufficient pulmonary reserve for surgery so radiation is an alternative |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 720-25. • Sternberg SS ed. Diagnostic Surgical Pathology, 2d edition, Lippincott-Raven; Philadelphia. 1996, pp. 1073-4. |
| Adenosquamous Carcinoma |
| Synopsis by: Melinda Sanders M.D. (T28000M85603)[437] |
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