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| Endobronchial Neoplasms |
| Etiology • Unknown. |
| Pathogenesis • Carcinoids exhibit Kulchitsky cell differentation • Salivary gland type neoplasms presumably arise from bronchial glands, |
| Epidemiology • Extremely uncommon. • More frequent in young patients <40 years. • Unrelated to cigarette smoking |
| General Gross Description • Polypoid tan mass protruding into the lumen of a major bronchus • Distal obstructive pneumonia may be profound with dilated mucous filled airways and consolidated firm parenchyma |
| General Microscopic Description • >90% of these neoplasms are carcinoid tumors • Remainder include low grade salivary gland malignancies such as adenoid cystic carcinoma and mucoepidermoid carcinoma • Microscopic findings are identical to same neoplasms at other body sites |
| Clinical Correlation • Cough with hemoptysis • Systemic symptoms of distal pneumonia including fever, malaise, sweats etc • Low grade neoplasms may metastasize to adjacent nodes • Many respond to removal of affected bronchus and lung • Alternative management can include laser ablation of the neoplasm |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 726-727. |
| Endobronchial Neoplasms |
| Synopsis by: Melinda Sanders M.D. (T28000M95800)[131] |
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