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| Abscess |
| Etiology • Secondary to inhalation, particularly of aspirated stomach contents • Unsucessfully treated or untreated bacterial infection • Embolized organisms e.g.from endocarditis • Trauma • Neoplasm • Miscellaneous including unknown |
| Pathogenesis • Generally due to necrotizing organisms such as gram positive and gram negative bacteria, as well as fungi, |
| Epidemiology • Immunocompromised patients are at risk as are • Individuals prone to aspiration such as alcoholics, comatose patients, or individuals with depressed gag or cough reflex |
| General Gross Description • Cavity in the lung with necrotic debris unless drained by bronchial tree • Wall generally irregular and shaggy • Most likely located in right lung if secondary to inhalation • May be anywhere if sequel to bronchopneumonia or septic emboli |
| General Microscopic Description • Destruction of pulmonary parenchyma • Often contains causative organism • Marked acute inflammation |
| Clinical Correlation • Cough with purulent sputum and pain • General symptoms such as fever and weight loss • Requires drainage and antibiotics for cure |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 699-700. |
| Abscess |
| Synopsis by: Melinda Sanders M.D. (T28000M46240)[120] |
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