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| Malignant Lymphoma |
| Etiology • Unknown. |
| Pathogenesis • Dependent on cell type • In general clonal proliferation of a lymphocyte line with maturation arrest, |
| Epidemiology • Varies depending on the cell type • Generally rare lesions if primary |
| General Gross Description • Difficult to visualize grossly unless forming mass which is fleshy and tan |
| General Microscopic Description • Dependent on the type of lymphoma • MALT-associated lesions exhibit interstitial and peribronchial/perivascular space involvement • Cells are round to oval with hyperchromatic nucleus and small nucleoli • Plasmacytoid differentiation may be seen • Lymphomatoid granulomatosis lesions (peripheral T cell derivation) are angiocentric and destructive • May be heterogeneous population ranging from small hyperchromatic irregular nuclei in scant cytoplasm to larger nuclei with multiple or single nucleoli |
| Clinical Correlation • Prognosis dependent on cell type • Small cell predominant lesions, either MALT associated or in lymphomatoid granulomatosis, carry better prognosis • In general the prognosis of lymphomatoid granulomatosis is poor |
| References • Sternberg SS ed. Diagnostic Surgical Pathology, 2d edition, Lippincott-Raven; Philadelphia. 1996, pp. 1011-15. |
| Malignant Lymphoma |
| Synopsis by: Melinda Sanders M.D. (T28000M95903)[438] |
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