| Diffuse small lymphocytic lymphoma
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Etiology
•Unknown
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Pathogenesis
•Unknown,
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Epidemiology
•Approximately 4% of all lymphomas fall into this class.
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General Gross Description
•Grossly, in common with all lymphomas, the affected
gland is enlarged and appears firm and homogenous in
consistency.
•On cross section, some of the finer details of lymph
node architecture may be lost giving rise to a uniform
fish-flesh appearance.
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General Microscopic Description
•Histologically, the node architecture is replaced by
uniform small cells which are apparently composed
entirely of a nucleus with little cytoplasm.
•The nuclear morphology resembles that of normal
lymphocytes.
•Atypical cells and mitoses are usually not seen.
•The cells express mature B lymphocyte markers, and in
addition, CD5, a marker associated with T lymphocytes.
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Clinical Correlation
•The prognosis of small lymphocytic lymphoma diffuse-type
is good.
•With extension to tissues beyond the lymph node (liver,
spleen and bone marrow), spillage of neoplastic cells
into blood may occur, with a leukemic picture.
•This condition is thus highly similar to chronic
lymphocytic leukemia.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 634
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| Diffuse small lymphocytic lymphoma
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| Synopsis by: T.V.Rajan, M.D., Ph.D. (T08000M96203)[591]
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