| Normal Bone Marrow
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Etiology
• Not applicable.
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Pathogenesis
• Not applicable.,
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Epidemiology
• Not applicable.
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General Gross Description
• Red in the young individual; yellow and fatty in the older individual
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General Microscopic Description
• In adult life the ratio of marrow elements to fat is 1:1
• Admixture of myeloid cells and erythroid cells in a ratio of 3:1
• Approximately 60% of cells are myeloid precursors including promyelocytes, metamyelocytes, myelocytes (with specific granules) and immature basophils, eosinophils and neutrophils
• Approximately 20% of cells are erythroid precursors with round dark nuclei
• Ten percent of cells are lymphoid including plasma cells
• Scattered megakaryocytes are also seen
• With age the marrow to fat ratio declines
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Clinical Correlation
•Not applicable
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 585-586.
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| Normal Bone Marrow
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| Synopsis by: Melinda Sanders M.D. (T06000M00100)[97]
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