| Adenocarcinoma in situ of Cervix
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Etiology
• Associated with human papilloma virus infection, especially type 18.
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Pathogenesis
• Viral integration into host cell genome in fully malignant cells.,
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Epidemiology
• Multiple sexual partners.
• Partner with multiple partners.
• Same as sexually transmitted disease.
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General Gross Description
• Not grossly recognizable.
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General Microscopic Description
• Columnar cells with enlarged, hyperchromatic nuclei
• Atypical nuclear chromatin
• Piling up of cells in epithelium with loss of polarity to surface
• Prominent nucleoli
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Clinical Correlation
• May be detected on routine pap smear but difficult to assess
• Usually found in conjunction with invasive disease
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1052.
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| Adenocarcinoma in situ of Cervix
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| Synopsis by: Melinda Sanders M.D. (T83300M81402)[275]
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