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| Chorangioma |
| Etiology •unknown? •hamartomas of primitive chorionic mesenchyme ? •benign tumor of fetal blood vessels? |
| Pathogenesis •unknown, |
| Epidemiology • occurs in approximately 1% of pregnancies |
| General Gross Description •when arise from villous tissue-usually close to the fetal surface, may bulge from placental surface •can arise from umbilical cord •well circumscribed •cut surfaces are fleshy, congested (red) •if infarcted, cut surface is tan |
| General Microscopic Description •external surface of tumor is covered by syncytiotrophoblasts •tumor resembles overgrown villus with extensive proliferation of vessels •may be infarcted with loss of nuclear detail |
| Clinical Correlation •small tumors--asymptomatic •large tumors--associated with hydramnios, antepartum hemorrhage, AV shunts that can lead to fetal heart failure, consumptive coagulopathy, microangiopathic hemolytic anemia |
| References •Benirschke,Kurt and Kaufmann,Peter Pathology of the Human Placenta, 2nd edition, New York: Springer-Verlag, 1990, p841-846. •Cunningham et al Williams Obstetrics, 19th edition Norwalk: Appleton and Lange, 1993, p759. |
| Chorangioma |
| Synopsis by: Linda Ernst (T88100M91200)[228] |
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