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Intervillositis (10X)
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Intervillositis (10X)

The villi are relatively large in this immature placenta.
The intervillus space contains an excess number of nucleated cells for normal circulating maternal blood, as demonstrated by the black arrow.
(Description By:Linda Ernst )
(Image Contrib. by:Linda Ernst UCHC )
Chronic Intervillositis ÿ
Etiology

Unknown
Pathogenesis

Unknonwn,
Epidemiology

May be associated with chronic non-specific villitis
May be associated with euploid spontaneous abortion
General Gross Description

No gross findings
General Microscopic Description

Accumulation of mononuclear cells (maternal CD3+ cells) in intervillous space
May accompany actual villitis
Clinical Correlation

May recur
May be associated with decidual vascular thrombosis and euploid early spontaneous losses.
References

Benirschke K, Kaufmann P. Pathology of the human placenta, 3rd ed. New York: Springer-Verlag, 1995, pp. 596-620.
Chronic Intervillositis ÿ
Synopsis by: Melinda Sanders M.D. (T88100M43000)[427]
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