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Trophoblast Inclusions (4X)
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Trophoblast Inclusions (4X)

This is a field of villi from an early spontaneous abortion.
The villi show extensive circulatory degneration.
Some villi have a smooth external contour wheras others show some complexity.
Inclusions are difficult to visualize at this power but should be searched for in villi with complex outlines.
(Description By:Melinda Sanders,M.D. )
(Image Contrib. by:Melinda Sanders,M.D. UCHC )
Trophoblast Inclusions
Etiology

Unknown.
Pathogenesis

Due to cross sections of deeply infolded villous contours,
Epidemiology

Increased in triploid gestations, particularly partial moles.
May also be increased in aneuploid gestations with other chromsome counts
General Gross Description

Microscopic finding
General Microscopic Description

Intravillus finding composed of syncytio- and/or cytotrophoblast
Maternal blood may be contained within the inclusion
Clinical Correlation

Outcome dependent on underlying pathology
References

Benirschke K, Kaufmann P. Pathology of the human placenta, 3rd ed. New York: Springer-Verlag, 1995, pp. 670-671.
Trophoblast Inclusions
Synopsis by: Melinda Sanders M.D. (T88100M20000)[425]
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