|
|
|
|
|
|
| Clear Cell Carcinoma |
| Etiology • unknown • associated with endometriosis • unrelated to diethylstilbesterol (DES) exposure |
| Pathogenesis • some patients with mutations in BRCA1 , |
| Epidemiology • peri- or post-menopausal women of low parity • gonadal dysgenesis • ovarian epithelial carcinoma = 6% of female cancer and 50% of female cancer deaths due to late detection and failure to determine high risk group • clear cell = 6% of ovarian cancers; 40% bilateral |
| General Gross Description • smooth, lobulated external surface • usually solid but may be cystic • yellow tan, firm |
| General Microscopic Description • cells arranged in tubules, nests, or cysts • clear cytoplasm (glycogen rich) with sharply demarcated cell borders • "hobnail" cells with nucleus standing on stalk of cytoplasm • hyperchromatic, pleomorphic nuclei |
| Clinical Correlation • early symptoms vague, late abdominal distension with ascites and pain • rarely detected on routine examination • Stage I confined to ovary(ies), II confined to pelvis, III with extension to abdominal cavity, IV distant metasases • most women Stage III or IV at presentation • spread across serosal surfaces and to lymph nodes • removal of bulk of tumor and chemotherapy are major therapy |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1065-1068 |
| Clear Cell Carcinoma |
| Synopsis by: Melinda Sanders M.D. (T87000M83103)[43] |
| Search Medline at National Library of Medicine Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window |
|
|
|
|
|
|