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| Acquired Cystic Disease |
| Etiology •Unknown. |
| Pathogenesis •Unknown. •One hypothesis is that abnormal tubular cell proliferation might be the means by which cysts develops in these end stage kidneys. •Another theory is that cysts develop from tubular obstruction by calcium oxalate crystals., |
| Epidemiology •By definition, this condition occurs in end stage renal disease. •This condition is apparently independent of the disease type that led to end stage kidney disease. |
| General Gross Description •Acquired cystic disease is defined as the development of cortical and medullary cysts in patients with end stage kidney disease from noncystic causes. •Both kidneys show multiple cysts of varying sizes in a background of sclerosing parenchymal changes. •Although many cysts are present, they are not as plentiful as in adult polycystic kidney disease. |
| General Microscopic Description •The cysts are lined by tubular epithelial cells that may be flat to cuboidal to hyperplastic. |
| Clinical Correlation •The clinical features are that of end stage renal disease. •The cysts themselves have no particular clinical correlates. •The most important concern with acquired cystic disease is the development of renal cell carcinomas. •The risk of developing renal cell carinomas is 100 times greater than in the general population. |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, p. 937. •Primer on Kidney Diseases 1994 (National Kidney Foundation), Arthur Greenberg editor. |
| Acquired Cystic Disease |
| Synopsis by: Harold Yamasel M.D. (T71000M33400)[245] |
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