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Cloaca
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Cloaca

The dilated sac-like structure in the center of the photograph is a persistent cloaca. There has been failure in early fetal life of the urorectal septum to divide the rectum from the urogenital sinus.
Entering the cloaca are the colon, the right ureter and the left ureter (there was left renal agenesis). The cloaca served as rectum and bladder. The infant had no anus.
The only outlet was a thin narrow urethra.
(Description By:H. Yamase, M.D. )
(Image Contrib. by: UCHC )
Persistent Cloaca
Etiology

Unknown.
Pathogenesis

The abnormality results from failure of the urorectal septum to separate the primitive urogenital sinus from the hindgut.,
Epidemiology

Developmental disorder detected prenatally or at birth.
General Gross Description

The diagnosis rests on the gross demonstration of a common structure serving as bladder and rectum.
General Microscopic Description

Not applicable.
Clinical Correlation

Associated anomalies may include imperforate anus, abscence of genital and urinary orifices, megacolon, megaureters, renal dysplasia, renal agenesis.
References

Textbook of Fetal and Perinatal Pathology. Wigglesworth JS and Singer DB (eds) Cambridge: Blackwell, 1989, pp. 1163-4.
Langman's Medical Embryology, 6th edition. 1990. Sadler TW. Baltimore: Williams and Wilkins. pp. 75, 255, 268.
Persistent Cloaca
Synopsis by: Harold Yamase M.D. (T74000M20000)[480]
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