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| Embryonal Carcinoma |
| Etiology •Unknown. •The tumor is a germ cell malignancy. |
| Pathogenesis •Unknown. •The tumor is a germ cell malignancy., |
| Epidemiology •Affects males in the third and fourth decades of life. |
| General Gross Description •On cut section, the tumor frequently shows irregular areas of necrosis and hemorrhage. •The tumor is variably demarcated from surrounding testis and structures. |
| General Microscopic Description •Histologically the tumor shows variable epithelial features including glandular and papillary structures and variable areas of undifferentiated sheets of tumor cells. •There are often areas of tumor necrosis and associated hemorrhage. •Cytologically, tumor cells show hyperchromatic pleomorphic nuclei with prominent sometimes multiple nucleoli. |
| Clinical Correlation •Affects males in the third and fourth decades of life. •Presents as testicular mass. •Elevated serum alpha fetoprotein and hCG detectable in 70 percent of cases. |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1017-1018. •Urological Pathology, Murphy WM (ed), Philadelphia: Saunders, 1989, pp. 330-336. |
| Embryonal Carcinoma |
| Synopsis by: Harold Yamase M.D. (T78000M90703)[466] |
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