| Tubular vacuolar change
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Etiology
•Hypokalemia.
•Uncontrolled diabetes
mellitus.
•Mannitol administration.
•Intravenous pyelography (contrast
induced).
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Pathogenesis
•Various substances in the tubular lumina can be reabsorbed into
tubular cells by pinocytotic vesicles which can then fuse with endogenous
lysozomes to produce large membrane bound vacuoles.
•Vacuolar change of
tubular cells is a reversible condition.,
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Epidemiology
•The epidemiology is diverse.
•Vacuolar change is a
non-specific cellular change.
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General Gross Description
•There are no specific gross
abnormalities.
•The finding is microscopic.
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General Microscopic Description
•The epithelial cells of the
proximal tubules show marked cytoplasmic vacuolization.
|
Clinical Correlation
•Patients may
manifest signs, symptoms and clinical laboratory values of acute renal
failure.
|
References
•Renal Disease Classification and Atlas of Tubulo-Interstitial
Diseases.Churg et.al. (eds.). New York: Igaku-Shoin, 1985 pp. 161,
168-171.
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| Tubular vacuolar change
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| Synopsis by: Harold Yamase M.D. (T71000M50070)[188]
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