| Cholesterolosis
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Etiology
•Unknown
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Pathogenesis
•Unknown,
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Epidemiology
•Incidental finding
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General Gross Description
•Characterized by abnormal deposition of mixtures of
cholesterol and triglyceride in macrophages in the
lamina propria of the gallbladder.
•The accumulating macrophages cause a distinctive bulge
and lift the superficial epithelium overlying them.
•The condition can either be localized or extensive and
diffuse.
•The latter is referred to as a "strawberry gallbladder".
•In a strawberry gallbladder, the mucosa tends to be red,
and is flecked with numerous yellowish spots.
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General Microscopic Description
•Histologically, the lesion is characterized by numerous
foamy macrophages lying just beneath the columnar
epithelium of the gallbladder.
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Clinical Correlation
•The condition has no clinical significance and is not
associated with any symptoms.
•There is no evidence that cholesterolosis predisposes
to cholelithiasis or cholecystitis.
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994.
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| Cholesterolosis
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| Synopsis by: T.V.Rajan, M.D., Ph.D. (T57000M55250)[585]
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