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| Pleomorphic Adenoma |
| Etiology • Unknown |
| Pathogenesis • Arise either from myoepithelial cell or reserve cell, |
| Epidemiology • Increased risk after radiation treatment • Most common benign neoplasm of salivary gland • Most common neoplasm of parotid • Present between 40-60 years of age |
| General Gross Description • Firm, gray, sometimes glassy neoplasm • Appears well circumscribed, although may have infiltrative borders microscopically |
| General Microscopic Description • Epithelial proliferation arranged in a variety of patterns including ductules, strands, or sheets • Variable stroma including a palely basophilic loose (myxoid) appearance • May be foci of cartilage or bone |
| Clinical Correlation • Slow growing mass • Unless completely excised will recur |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 749-750. |
| Pleomorphic Adenoma |
| Synopsis by: Melinda Sanders M.D. (T55100M89400)[325] |
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