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| Cytomegalovirus Infection |
| Etiology • Cytomegalovirus, beta-group herpesvirus |
| Pathogenesis • Viral infection of endothelium and epithelial cells as well as stromal cells • Productive infection results in viral cytopathic changes described below • Endothelial cell damage can lead to vascular injury, |
| Epidemiology • Widely distributed in normal population where it is acquired sexually, perinatally, in breast milk, intrauterine or by respiratory droplets • Causes asymptomatic or mononucleosis like infection; latent in leukocytes • In immunocompromised patient's becomes disseminated |
| General Gross Description • Discrete ulcers when endothelial cell involvement pronounced. • May perforate. |
| General Microscopic Description • Cytopathic changes associated with viral infection and replication include marked cellular enlargement. • Large intranuclear and/or intracytoplasmic eosinophilic inclusions • Intranuclear inclusions occupying >50% of nuclear diameter are diagnostic • Necrosis with endothelial cell involvement |
| Clinical Correlation • May result in perforation • Bloody diarrhea |
| References • Diagnostic Surgical Pathology, 2d edition, Sternberg SS (ed). Philadelphia: Lippincott-Raven,1996, pp. 1335. |
| Cytomegalovirus Infection |
| Synopsis by: Melinda Sanders M.D. (T64000E32230)[531] |
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