| Mycobacterium Avium Complex Infection
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Etiology
• Mycobacterium avium and other closely associated organisms including M. intracellulare, and M. scrofulaceum, ubiquitous in the environment.
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Pathogenesis
• Organisms disseminate throughout the body
• Accumulate within macrophages in the lamina propria,
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Epidemiology
• Found in immunocompromised host, specifically patients with HIV infection.
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General Gross Description
• May appear normal.
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General Microscopic Description
• Macrophages within lamina propria contain foamy macrophages.
• Numerous organisms can be identified within the macrophages with acid fast stains
• Little to no inflammatory response.
• Superficial resembalnce to Whipple's disease
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Clinical Correlation
• Part of disseminated disease.
• Drug regimens to treat as well as prevent disease available.
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References
• Diagnostic Surgical Pathology, 2d edition, Sternberg SS (ed). Philadelphia: Lippincott-Raven,1996, pp. 1335.
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| Mycobacterium Avium Complex Infection
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| Synopsis by: Melinda Sanders M.D. (T64000E20170)[530]
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