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Metastatic Adenocarcinoma (Cross Section)
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Metastatic Adenocarcinoma (Cross Section)

The arrows point to a gray white area obscuring the normal architecture of cortex and medulla.
The gray white area is metastatic carcinoma.
The cortex is vivid yellow.
The medulla is brown to gray.
(Description By:Melinda Sanders, M.D. )
(Image Contrib. by: Saint Francis Hospital )
Metastatic Adenocarcinoma
Etiology

Unknown.
Pathogenesis

Arrive via systemic circulation
Unknown why lung carcinoma has predilection for adrenals,
Epidemiology

Up to 25% of patients with metastatic carcinomas
Lung and breast predominate
Also GI tract, thyroid, kidney, other adrenal
General Gross Description

May be cortical or medullary, tan with or without hemorrhage or necrosis.
General Microscopic Description

Resembles primary site
Clinical Correlation

Requires chemotherapy to treat.
May be associated with mild adrenal failure.
References

Diagnostic Surgical Pathology, 2d edition, Sternberg SS (ed). Philadelphia: Lippincott-Raven,1996, pp. 585-6.
Metastatic Adenocarcinoma
Synopsis by: Melinda Sanders M.D. (T93000M81406)[444]
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