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| Papillary Carcinoma |
| Etiology • Unknown |
| Pathogenesis • Unknown. ?BRCA1 mutations, see discussion under infiltrating duct carcinoma., |
| Epidemiology • Approximately 1-2% of breast carcinoma |
| General Gross Description • Usually 2-3 cms in size • Approximately 1/2 located beneath the nipple (associated with bloody nipple discharge) • Well-circumscribed • Cystic lesions contain brown mixture of blood clot and neoplastic tissue |
| General Microscopic Description • Intracystic variant may be difficult to separate from papilloma but lacks myoepithelial cell proliferation • Stroma of the papillae is delicate compared to a papilloma • Piled up epithelial cells with nuclear hyperchromasia and mitotic activitiy • Periphery of cyst is fibrotic and distinguishing invasion may be difficult unless neoplasm reaches fat |
| Clinical Correlation • When non-invasive prognosis is similar to other intraductal carcinoma • When invasive carries a significantly better prognosis than usual ductal carcinoma |
| References • Rosen PP, Oberman H. Tumors of the Mammary Gland.Washington, AFIP, 1993, pp. 209-218. |
| Papillary Carcinoma |
| Synopsis by: Melinda Sanders M.D. (T04000M82603)[310] |
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