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| Infiltrating Lobular Carcinoma |
| Etiology • Unknown |
| Pathogenesis • Unknown •? BRCA1 mutations, |
| Epidemiology • Between 3-14% of invasive carcinomas of the breast depending on microscopic criteria for diagnosis • More common in older women with breast cancer |
| General Gross Description • Mass may be firm to hard or not readily palpable or visible • May be detected mammographically, although microcalcifications are uncommon |
| General Microscopic Description • Neoplastic cells infiltrate in small linear groups: "Indian file" • Circle around preexisting benign ducts forming a "target" • Some variants are recognized with solid, tubulolobular or alveolar patterns • Intracytoplasmic lumens may be identified by electron microscopy • Mucin vacuoles creating a signet ring appearance with a nucleus pressed against the cytoplasmic membrane by a large mucin vacuole may be seen. |
| Clinical Correlation • Bilaterality ranges from 6-28% • Neoplasms spread to axillary lymph nodes and then disseminate to lungs, liver, and bone • Therapy dependent on stage with treatment similar to that with invasive duct carcinoma |
| References • Rosen PP, Oberman H. Tumors of the Mammary Gland. Washington, AFIP, 1993, pp. 168-175. |
| Infiltrating Lobular Carcinoma |
| Synopsis by: Melinda Sanders M.D. (T04000M85203)[315] |
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