Low power view of an area of myelofibrosis

Low power view of an area of myelofibrosis •A low power view of an area of myelofibrosis. •Running from the left bottom towards the right top is a spicule of normal bone. •Normally, the rest of this image would be composed of marrow elements including fat cells and hemopoietic islands. •Instead, this marrow space is replaced by abundant collagen, represented by the eosinophilic staining fibrous material towards the center of this image, and a looser, more faintly staining stroma with abundant fibroblasts. (Description By:T.V.Rajan, M.D. ) (Image Contrib. by:T.V.Rajan, M.D. UCHC )