High power view of an area of myelofibrosis

High power view of an area of myelofibrosis •A medium high power view of myelofibrosis. •To the left is a spicule of normal bone. •To the right top of this image (highlighted by the black arrows) is a small fragment of new bone formation. •The recent origin of this bone is indicated by the large number of osteocytes relative to the matrix. •Notice that in the more mature bone to the left, far fewer osteocytes are visible in the lacunae. •The rest of the image is composed of immature fibrous connective tissue instead of the normal marrow elements. •The immaturity of this collagen is indicated by the relatively cellular appearance. •It would be useful to contrast this with mature collagen, best seen in the image entitled "Dermal fibroblasts." (Description By:T.V.Rajan, M.D. ) (Image Contrib. by:T.V.Rajan, M.D. UCHC )