Low Power view of synovial chondromatosis

Low Power view of synovial chondromatosis •A high power view of the center of a synovial chondromatosis lesion. •The black arrows point to an area of cartilage within the center of this lesion. •The black asterisks point to the area in which bone is beginning to develop, with osteocytes secreting dark pink staining osteoid matrix. •The central deep blue staining material, highlighted by the three green arrows point to an area where the osteoid matrix has already undergone mineralization. •The deep blue color is due to the calcium apatite deposits in the osteoid matrix. •The phosphate groups in apatite, being negatively charged, bind to the positively charged hematoxylin dye in the routine H+E strain. •Bone formation at the center of a synovial chondromatosis lesion is quite common. (Description By:T.V.Rajan, M.D. ) (Image Contrib. by:T.V.Rajan, M.D. UCHC )